Instrumentation Bruker DRX600K 600 MHz NMR Spectrometer (Narcissus) 3 high power channel operation 5 mm triple nucleus (C, N, H) inverse probe with XYZ gradients X, Y and Z-field gradients Pentium 4 2.6 GHz PC with 21" Sony Trinitron monitor VT unit (-20 to 120 °C) Bruker DPX400 400 MHz NMR Spectrometer (Echo) 2 high power channel operation 5 mm quadruple nucleus (H, C, F & P) probe with Z gradient 5 mm broadband (109Ag to 31P) inverse probe with Z gradient and 3H to 19F decoupling Z-field gradients SGI O2 workstation with 19" Sony monitor Pentium 3 750 MHz PC with 21" Sony Trinitron monitor for data processing Karuso Group VisLab: Laboratory for Molecular Visualisation and Structure Generation SGI - Octane, INDIGO2 (High Impact), 2xINDY, INDIGO Bruker - software: XWinNMR3.5 and 2.6, NMRGuide and Aurelia2.7.5 Xeasy - NMR assignment package. Pencil - NMR simulation software Xplor - NMR and crystallographic structure refinement package. Gromos96 - MD engine and structure refinement tool. Biosym Suite - release 2000 (Insight, Analysis, Biopolymer, Discover, Turbomol). Macromodel / Batchmin - general modeling package. Modeller - protein homology modeling program. Molmol - visualisation and rendering front-end. DRAGON - protein modelling tool using the Distance Geometry method developed at the Division of Mathematical Biology of the National Institute for Medical Research in London. Babel - file conversion utility. Cambridge Structural Database on CD Brookhaven Protein Database on CD See the Macquarie VisLab homepage for further hardware and software.