Profile for Dr Fei Liu

• Development of catalytic and stereo-specific reactions for efficient generation of useful small molecules as synthetic building blocks or biological probes. 
• Small molecule-based chemical description and understanding of phenotypic variation for studying cancer or antibiotic resistance. 
• Chemistry and biology of post-translational modifications of enzymes or proteomes.

"Phagemid Encoded Small Molecules for High Throughput Screening of Chemical Libraries" Yin, J.; Liu F.; Schinke, M.; Daly, C.; Walsh, C. T.,  J. Am. Chem. Soc. 2004, 13570-1. 

"Hybrid Nonribosomal Peptide-Polyketide Interfaces in Epothilone Biosynthesis: Minimal Requirements at N- and C- Termini of EpoB for Elongation" Liu, F.; Garneau, S.; Walsh, C. T.,  Chem. Biol. 2004, 1533-42. 

"Labeling proteins with small molecules by site-specific posttranslational modification" Yin, J.; Liu F.; Li, X.; Walsh, C. T.,  J. Am. Chem. Soc. 2004, 7754-5-1. 

"Cross-System Enzyme Module Recognition for Combinatorial Biosynthesis: Linker-Dependent Interface between the Biosynthetic Pathways of Yersiniabactin and the Epothilones" O'Connor, S. E.; Walsh, C. T.; Liu, F.,  Angew. Chem. Int. Ed. 2003, 3917-21. 

"Adenosine-Anchored Triphosphate Subsite Probing: Distinguishing between HER-2 and HER-4 Tyrosine Protein Kinases" Liu, F.; Johnson, E F.; Austin, D. J.; Anderson, K. S., Bioorg. Med. Chem. Lett. 2003, 3587-92.

"A General Synthesis of 5'-Azido-5-Deoxy-2',3'-O-Isopropylidene Nucleosides" Liu, F.; Austin, D. J., J. Org. Chem., 2001, 8643-5.

"Synthesis of a New Class of 5'-Functionalized Adenosines using a Rh (II)-Catalyzed 1,3-Dipolar Cycloaddition" Liu, F.; Austin, D. J., Org. Lett. 2001, 2273-6.

fliu@alchemist.chem.mq.edu.au  

Fei obtained her BSc (Magna) in Chemistry from John Carroll University (University Heights, Ohio) and a PhD in Organic Chemistry from Yale University (New Haven, Connecticut). The research perspective formed at Yale, which is to study and understand biological phenomena, such as cancer, with the techniques and principles of physical and organic chemistry, led to an NIH postdoctoral fellowhip with C.T. Walsh in the Department of Biological Chemistry and Molecular Pharmacology at the medical school of Harvard University (Boston, Massachusetts). In the Walsh lab she had the opportunity to work with, and learn from, 20 other postdoctoral fellows and graduate students with a wide range of backgrounds from total synthetic chemistry to bacterial genetics, all working collaboratively to study biosynthetic enzymes and their therapeutic implications in cancer and antibiotic resistance. In 2004 Fei accepted a lecturership with the Department of Chemistry at Macquarie University. The current phase of her research focuses on developing efficient synthetic methods for accessing small molecules with useful properties in chemistry and biology. Her long-term interest in chemical proteomics along with its applications in basic biological discovery and medicine is being pursued in close collaboration with the Australian Proteomics Analysis Facility (APAF).

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BS in Chemistry
John Carroll University
PhD in Organic Chemistry
Yale University